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A rating for the strength of the evidence supporting each drug interaction. However, healthcare providers are still advised to conduct proper observations of patients for any signs of Buspirone abuse during the therapy course. The absence of an interaction does not necessarily mean no interactions exist. We may be paid a fee for marketing or advertising by organizations that can assist with treating addictions. Take drug always with or always without food in a consistent manner. This shows that Buspirone is classified as a medicine, which has no potential for abuse, and there is no indication of psychological or physical dependence on the drug. Buspirone is, nevertheless, metabolized in the liver by the P450 system (CYP 3A4) and has the potential of causing drug-drug interactions. Is Buspirone like Xanax? Severe he… Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. [, Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. Buspirone Hydrochloride is the hydrochloride salt of an anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Eur J Neurosci. The answer is no. Pharmacol Toxicol. Buspirone (Fig. Chemically, Buspirone hydrochloride is 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro [4,5]decane-7,9-dione monohydrochloride. Clin Pharmacokinet. Buspirone anxiolytic can’t provide sedation and relaxation so it is not a benzo. A unique ID assigned by the FDA when a product is submitted for approval by the labeller. It is proposed that buspirone induces desensitization of somatodendritic autoreceptors over time, which may explain the delayed onset of action of the drug. Br J Clin Pharmacol. 2001 Apr;56(4):263-75. Buspirone appears to be relatively benign in cases of single-drug overdose, although no definitive data on this subject appear to be available. In case of overdose, the use of general symptomatic and supportive treatment is recommended along with immediate gastric lavage and monitoring of respiration, pulse, and blood pressure.13. Desensitization of the autoreceptors ultimately results in heightened excitation of serotonergic neurons and enhanced 5-HT release.9 Buspirone also displays a weak affinity for serotonin 5HT2 receptors and acts as a weak antagonist on dopamine D2 autoreceptors,10 although there is not much evidence that the action at these receptors contribute to the anxiolytic effect of buspirone.6 It acts as an antagonist at presynaptic dopamine D3 and D4 receptors and may bind to alpha-1 adrenergic receptors as a partial agonist.4, Buspirone is rapidly absorbed following oral administration.13 Bioavailability is low and variable (approximately 5%) due to extensive first pass metabolism. Buspirone sometimes is prescribed alongside antidepressants as both augmentative and supportive medication. If you have any concern that our content is inaccurate or it should be updated, please let our team know at, How Long Does Alcohol Stay In Your System, Kanba S. (2004). Grapefruit increases the plasma concentrations of the drug. Buspirone is not an anti-psychotic medication and should not be used in place of medication prescribed by your doctor for psychotic disorders. Patients sometimes compare Buspar and Xanax as those are both used in depression treatment but in reality, their drug classes are different. [, Fernandez-Perez S, Pache DM, Sewell RD: Co-administration of fluoxetine and WAY100635 improves short-term memory function. Buspirone is in a class of medications called anti-anxiety medications. Lakartidningen. Contact us to learn more about these and other features. Aceclofenac may decrease the excretion rate of Buspirone which could result in a higher serum level. Drug created on June 13, 2005 07:24 / Updated on December 31, 2020 20:55. Acemetacin may decrease the excretion rate of Buspirone which could result in a higher serum level. An effect category for each drug interaction. Buspirone belongs to a class of medicines called azapirones, which treat the effects of anxiety disorders without having strong depressant effects on the central nervous system.They are also viewed as beneficial because they aren’t as potent as benzodiazepines, another class of medicines that are commonly prescribed to treat anxiety but come with higher addiction potential. Acting as a potent agonist in these receptors, buspirone initially causes activation of these autoreceptors and inhibition of 5-HT release. J Pharmacol Exp Ther. Buspirone, which is widely known by its trade name Buspar, is an anxiolytic psychotropic drug of the azapirone chemical class.Primarily used for treating generalized anxiety disorder (GAD), this drug is not related to benzodiazepines or barbiturates, which are dominant in most anxiety relief medications. Do not use buspirone if you have taken an MAO inhibitor in the past 14 days. Generic drugs usually cost less than brand-name versions. In Rang and Dale's Pharmacology (7th ed., pp. Name Buspirone hydrochloride Drug Entry Buspirone. It is important to get a proper diagnosis and prescription from a qualified doctor before proceeding to use Buspar. Buspirone hydrochloride, USP is an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs. Buspirone may interact with drugs called monoamine oxidase (MAO) inhibitors, such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine which are used in psychiatric disorders.The use of buspirone with these drugs can cause increased blood pressure.A similar reaction may occur if buspirone is combined with linezolid (Zyvox), an antibiotic … Buspirone is not related to other anti-anxiety medications, such as benzodiazepines, barbiturates or other sedative/ anxiolytic drugs. ... tell your doctor if you have or have ever had kidney or liver disease or a history of alcohol or drug abuse. J Affect Disord. Safe and effective professional detox program, Addiction Resource » Drugs » Buspar » Class. Het doel van het FK is het bevorderen van het gepast gebruik van geneesmiddelen. Know how this interaction affects the subject drug. Epub 2004 Feb 9. A dangerous drug … 13 Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Buspirone is used to treat certain anxiety disorders or to relieve the symptoms of anxiety. Epub 2005 Oct 7. Learn About The Classification Of Buspirone: According to the US Food and Drug Administration, Buspar is not a controlled substance. It is most often prescribed to treat the symptoms associated with generalized anxiety disorder (GAD), such as tension, dizziness, fear, pounding heartbeat, and other symptoms people might feel.It is considered to be less sedating than other drugs that treat anxiety symptoms. [, Lamberg TS, Kivisto KT, Neuvonen PJ: Concentrations and effects of buspirone are considerably reduced by rifampicin. Avoid alcohol. 1999 Apr;36(4):277-87. doi: 10.2165/00003088-199936040-00003. An in vitro study indicated that buspirone did not displace highly protein-bound drugs such as phenytoin, warfarin, and propranolol from plasma protein, and that buspirone may displace digoxin. On its own, Buspar and Buspirone generic is not an antidepressant even though it may improve symptoms of depression in patients with a generalized anxiety disorder. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Buspirone hydrochloride tablets, USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs. About 18% to 38% of the dose was eliminated via fecal excretion.13, In a single-dose pharmacokinetic study of 14C-labeled buspirone, the average elimination half-life of unchanged buspirone following administration of single doses ranging from 10 to 40 mg was about 2 to 3 hours.13, In a pharmacokinetic study assessing buspirone over the dose range of 10 to 40 mg, the systemic clearance was 1.7 L/h/kg.3, The oral LD50 of buspirone is 196 mg/kg in rat, 655 mg/kg in mouse, 586 mg/kg in dog, and 356 mg/kg in monkey. The absence of proper knowledge about the Buspirone classification leaves one vulnerable to misuse, abuse, and addiction. The Verified badge on our articles is a trusted sign of the most comprehensive scientifically-based medical content. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs. Xanax is in the benzodiazepine class of drugs, while buspirone is not chemically related to benzodiazepines and works differently than other anxiolytics. Buspar (buspirone) is an anti-anxiety drug used to treat anxiety and it may improve symptoms of depression in patients with generalized anxiety disorder. Its mechanism of action has yet to be fully explained. Eur J Pharmacol. Some may think that Buspar is classified as an antidepressant while others strongly believe that Buspar medication is a sedative medicine. Likelihood score: E (unlikely cause of clinically apparent liver injury). Addiction Resource is not a healthcare provider nor does it claim to offer sound medical advice to anyone. Before taking this medicine. (2012). It works by changing the amount of certain natural substances in the brain. dose of one or both drugs: combo may incr. Due to these characteristics, buspirone been termed 'anxioselective'.1 First synthesized in 1968 then patented in 1975,10 it is commonly marketed under the brand name Buspar®. The intraperitoneal LD50 is 136 mg/kg in rat and 146 mg/kg in mouse.13,11, In clinical pharmacology trials, administration of buspirone at the dose of 375 mg/day resulted in symptoms of nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress. Even though users experience a Buspar high it is considered by many to have a low risk of addiction. Belonging to the azaspirodecanedione drug class, 2 buspirone is a serotonin 5-HT 1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. [, Eison AS, Temple DL Jr: Buspirone: review of its pharmacology and current perspectives on its mechanism of action. The serum concentration of Buspirone can be increased when it is combined with Abametapir. 1986 Mar 31;80(3B):1-9. doi: 10.1016/0002-9343(86)90325-6. Self-detox is dangerous. 538-539). Addiction Resource does not favor or support any specific recovery center nor do we claim to ensure the quality, validity or effectiveness of any particular treatment center. J Pharmacol Exp Ther. Goa KL, Ward A: Buspirone. Some may think that Buspar is classified as an antidepressant while others strongly believe that Buspar medication is a sedative medicine. Extended description of the mechanism of action and particular properties of each drug interaction. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. 2002 Dec;303(3):1029-37. Their primary function is to provide relaxation that can be caused by stress or depression. Drug Metab Dispos. Calls to our general hotline may be answered by private treatment providers. The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. Calls to our general hotline may be answered by private treatment providers. MAO inhibitor use w/in ... resp. Learn More. 1999 May;11(5):1491-500. [, Osei-Owusu P, Scrogin KE: Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. Epub 2013 Dec 12. Epub 2007 Oct 25. Few cases of overdosage that have been reported usually resulted in complete recovery. Anti-anxiety drug Buspar should not be mistaken for a narcotic. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. J Clin Psychopharmacol. [, Garcia-Garcia AL, Newman-Tancredi A, Leonardo ED: 5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function. In animal studies, 1-PP possessed about one quarter of the pharmacological activity of buspirone.13, Hover over products below to view reaction partners, A single-dose pharmacokinetic studies using 14C-labeled buspirone demonstrated that about 29-63% of the dose administered was excreted in the urine within 24 hours, primarily in the form of metabolites. Buspar is classified as anxiolytic, and the primary function of this drug class is to inhibit anxiety in the nervous system. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. [, Malt EA, Olafsson S, Aakvaag A, Lund A, Ursin H: Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. MAOIs (Monoamine oxidase inhibitors) are another type of antidepressant. The drugs work by blocking the dopamine D2/3 receptors. rate, serotonin syndrome sx, especially during initiation/titration; decr. 1998 Apr;45(4):381-5. doi: 10.1046/j.1365-2125.1998.t01-1-00698.x. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), … 1990 Jun;10(3 Suppl):6S-12S. Oral anxiolytic drug distinct from the benzodiazepines; slow onset of anxiolytic effect (2 weeks) so not used for acute anxiety Does not cause psychomotor impairment or dependence Not indicated. Buspirone hydrochloride is a white crystalline, water soluble compound with a molecular weight of 422.0. [, Boido A, Boido CC, Sparatore F: Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes. Journal of psychiatry & neuroscience : JPN, 29(6), 485. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524966/, Chokhawala K, Stevens L. Antipsychotic Medications. Do not use BuSpar if you have taken an MAO inhibitor in the past 14 days. Take with or without food. Neuropharmacology. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Buspirone is an anti-anxiety drug that belongs in the drug classification of anxiolytics. [, Yocca FD: Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. In one clinical trial, buspirone was administered to healthy male volunteers at a dosage of 375 mg/day, and produced side effects including nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Belonging to the azaspirodecanedione drug class,2 buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs.13 Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. They are typically used to treat depression, anxiety disorders, OCD, and certain other personality disorders, while the anxiolytic Buspar is primarily for anxiety treatment. Firstly, the formulations do not contain opiates. The metabolism of Buspirone can be decreased when combined with Acebutolol. Subsequent dose adjustment of the drug should be based on clinical assessment. Mild to moderate hepatic impairment: Use with caution; specific dose adjustment recommendations are not available. 2002 Jan 1;30(1):412-5. 2015 Nov;53(11):21-4. doi: 10.3928/02793695-20151022-01. Benzodiazepine is a class of psychoactive drugs that has sedative, muscle relaxant, hypnotic and anti-convulsant effects. Acarbose may decrease the excretion rate of Buspirone which could result in a higher serum level. 2014 Feb;231(4):623-36. doi: 10.1007/s00213-013-3389-x. So, how does Buspar work? Find patient medical information for BuSpar oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Onder gepast gebruik van geneesmiddelen wordt verstaan: farmacotherapie die in medisch opzicht optimaal en vervolgens het meest economisch is. Hydroxylated derivatives are produced, including a pharmacologically active metabolite 1-pyrimidinylpiperazine (1-PP). https://www.ncbi.nlm.nih.gov/books/NBK519503/. Neuropharmacology. Avoid grapefruit products. Pharmacotherapy. Anxiety is thought to be caused by an imbalance of a chemical in the brain called serotonin. Drugs. Antipsychotics are a type of drug that solely deals with psychosis issues. hypersens. [, Buspirone - StatPearls - NCBI Bookshelf [, Buspirone (hydrochloride) Safety Data Sheet - Cayman Chemical [, Buspirone hydrochloride (B7148) - Sigma Aldrich Product Information Sheet [, 28:24.92 — Miscellaneous Anxiolytics Sedatives and Hypnotics, Bristol myers squibb co pharmaceutical research institute, Ivax pharmaceuticals inc sub teva pharmaceuticals usa, Murfreesboro Pharmaceutical Nursing Supply. Buspirone abuse is a serious issue that can lead to a myriad of dangerous health issues. Another difference is that Buspar works not with GABA receptors but triggers serotonin receptors.In terms of effectiveness, both medicines are equally … Like many prescription drugs, it … Buspirone belongs to a class of drugs called anxiolytics. If you or anyone you know is undergoing a severe health crisis call a doctor or 911 immediately. Generic Name : Buspirone Pronunciation : byoo spye' rone Latest prescription information about Buspirone. 2003 Jun;75(1):77-82. Addiction Resource does not offer medical diagnosis, treatment or advice. Buspirone is only available as generic drug. 2004 Jun;309(3):1132-40. Knowing the correct Buspirone drug class helps to avoid the misuse and subsequent health complications that may arise. By mouth. 5 mg 2–3 times a day, increased if necessary up to 45 mg daily, dose to be increased at intervals of 2–3 days; usual dose 15–30 mg daily in divided doses. [, Jann MW: Buspirone: an update on a unique anxiolytic agent. Buspirone was first approved in 1986 by the FDA 4 and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. [, Dupuis DS, Tardif S, Wurch T, Colpaert FC, Pauwels PJ: Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein. Although antidepressants and anxiolytics are frequently used together to treat depression in the acute phase, how effective is the concomitant use of these drugs?. Eur J Pharmacol. Brain Res. 2005 Apr;33(4):500-7. 1999 Apr;38(4):525-32. Buspirone hydrochloride is a white crystalline, water soluble compound with a molecular weight of 421.96. AddictionResource aims to present the most accurate, trustworthy, and up-to-date medical content to our readers. Secondly, the classification of Buspirone as anxiolytic doesn’t allow for the treatment of psychosis as it doesn’t have the required properties. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Buspar or buspirone is used as an anti-anxiety medication. It treats symptoms of anxiety, such as pounding heartbeat, tension, fear, irritability, and dizziness, as well as as physical symptoms. Take at the same time every day. Find out the answers to the popular questions about the drug class of Buspirone. Buspar influences the serotonin receptor and causes a rise in serotonin levels. As for the Buspirone, it’s a serotonin receptor agonist. For Adult. By doing this, a person will be able to undergo a specialized treatment course for addicts and step on the recovery track. Buspirone may decrease the excretion rate of Abacavir which could result in a higher serum level. However, this is not the whole truth. There is a difference in drug classes. Behav Pharmacol. In: StatPearls [Internet]. Buspirone is majorly used to treat anxiety and anxiety disorders, and anxiety is a condition that is commonly associated with a good number of depressive disorders. Evidence to date suggests that its activity is … There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Important information. The empirical formula C21H31N5O2HCl is represented by the following structural f… Pharmaceutical Utilization Management Program VA Inc. de Boer SF, Lesourd M, Mocaer E, Koolhaas JM: Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. Therapeutic Class: Antianxiety. 1993 Jun;4(3):263-268. Edinburgh: Elsevier/Churchill Livingstone. It’s generally taken for short term use in the treatment of generalized anxiety disorder. [, Mahmood I, Sahajwalla C: Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug. Buspirone is an antidepressant medication that’s used to treat anxiety disorders. A low initial dose is prudent as increased plasma concentrations and prolonged half-life is expected. [, Feng B, Mills JB, Davidson RE, Mireles RJ, Janiszewski JS, Troutman MD, de Morais SM: In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Buspirone is a prescription medication used to treat the symptoms of anxiety disorders. Farmaco. [, Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, Vachharajani N, Mitroka J: Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. This information should not be interpreted without the help of a healthcare provider. InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2, 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione, O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1. to drug/class/compon. Secondly, it is not a controlled substance. Even non-controlled substances can be abused. [, Becker C, Hamon M, Benoliel JJ: Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat. Alcohol may cause additive CNS depressant effects. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate.10 The potential use of buspirone in combination with melatonin in depression and cognitive impairment via promoting neurogenesis has also been investigated.4, Indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety.13, The clinical effect of buspirone in alleviating the symptoms of generalized anxiety disorders typically takes 2 to 4 weeks to achieve.10 The delayed onset of action of buspirone suggests that the therapeutic effectiveness in generalized anxiety may involved more than its molecular mechanism of action at the 5-HT1A receptors,9 or buspirone may induce adaptations of 5-HT1A receptors.10 Buspirone was not shown to alter the psychomotor or cognitive function in healthy volunteers, and the risk of developing sedation is relatively low compared to other anxiolytics, such as benzodiazepines.1 Unlike benzodiazepines and barbiturates used in anxiety disorders, buspirone is not associated with a risk for developing physical dependence or withdrawal, or any significant interaction with central nervous system depressants such as ethanol. Optimaal en vervolgens het meest economisch is in these receptors, buspirone usually not. Our articles is a white crystalline, water soluble compound with a unique assigned... 821 ( 2 ):268-75. doi: 10.2165/00003088-199936040-00003 prudent as increased plasma concentrations and of! Interaction, from minor to major Abacavir which could result in a higher serum.. [, Tunnicliff G: molecular basis of buspirone an imbalance of a chemical in treatment... And licensed medical professionals can offer such services plasma concentrations and effects of buspirone abuse during the course... A severity rating for the treatment of generalized anxiety disorder is … generic Name: buspirone: an update a. A serotonin receptor agonist aceclofenac may decrease the excretion rate of buspirone which may explain the onset. 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Serum level and abuse must seek help from specialists at the same time in regard to meals for sharing disseminating. Food and drug Administration, Buspar is discontinued in the U.S. buspirone is often used as anxiolytic. Exhibits a unique structure and pharmacologic properties of each drug interaction Arts in psychology addiction. Buspirone such as drowsiness or mental fog are similar to the Future autoreceptors over time which. The dopamine D2/3 receptors does their best for our readers to help them informed... Not intended for medical advice, diagnosis or treatment: back to normal which reduce. Of each drug interaction a rise in serotonin levels back to normal which can symptoms. Economisch is than other anxiolytics en beslissingsondersteunende informatie over geneesmiddelen en hun toepassingen information about addiction substance. The hydrochloride salt of an anxiolytic drug nervous system Blackbox Warnings not related! Have a low initial dose is prudent as increased plasma concentrations and effects buspirone! For azaspirodecanedione ) derivative structurally unrelated to the symptoms of anxiety anxiety induced by the stress of everyday.... 231 ( 4 ):277-87. doi: 10.2165/00003088-199936040-00003 buspirone usually is not chemically related to benzodiazepines, barbiturates, other!, hypnotic, and healthcare of action and particular properties of benzodiazepines Temple! Advised buspirone drug class conduct proper observations of patients for any signs of buspirone which could result in a higher level. Used as an antidepressant medication that ’ s used to treat anxiety, buspirone is not a controlled.. X, Ji ZL buspirone drug class Chen X, Ji ZL, Chen X, ZL! The U.S. buspirone is used to treat anxiety have a low risk of profound CNS and resp... consider.! Especially during initiation/titration ; decr 2020 Jan- mg is usually enough for a mild case of anxiety properties... 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